The acetylcholine receptor

the nature of acetylcholine receptor

the present work with consideratlon to the autoradiographic pictures, suggests that cholinergic receptors are located at the gate of a channel originating from synaptic cleft coming to lie within the muscle fibre. ache molecules stand at the gate of this channel,controlling the entrance of different cholinergic agents. it was report- ••• ed previously that dtc molecules s t.abd ;:.2e the ache r...

Conformation of acetylcholine bound to the nicotinic acetylcholine receptor.

We report here the biologically active conformation of acetylcholine when bound to the high-affinity state of the receptor from Torpedo californica. The acetylcholine conformation was determined in the free and bound states by proton NMR two-dimensional nuclear Overhauser effects. In agreement with x-ray crystallographic data, acetylcholine in solution has an extended conformation with an avera...

Muscle Acetylcholine Receptor Biosynthesis

The expression of the muscle nicotinic acetylcholine receptor (AChR) on the cell surface entails a complex biosynthetic pathway, involving the expression and assembly of four subunits. The amount of AChR on the cell surface changes throughout muscle development and upon muscle denervation. We have examined the regulatory role of transcript levels on surface AChR expression by RNA blot analysis....

The molecular neurobiology of the acetylcholine receptor.

Introduction The acetylcholine receptor (AChR) is the most thoroughly characterized component of the neuromuscular transduction process. Earlier reviews that summarize the structural and biochemical features of the AChR include Popot & Changeux (1984), Stroud (1983), Conti-Tronconi & Raftery (1982), and Karlin (1980). This receptor translates the binding of the neurotransmitter, acetylcholine (...

Allosteric transitions of the acetylcholine receptor.